Common Side Effects of PRP

What is PRP?

Platelet-rich plasma (PRP) therapy is a popular treatment in aesthetic medicine and sports medicine. It involves a sample of the patient’s own blood, which is processed to extract the plasma rich in platelets. And in other cases growth factors, which is then re-injected back into the body to stimulate tissue repair and rejuvenation.

What are the Common Side Effects of PRP?

PRP is generally considered safe, however there are some common side effects that patients should be aware of:

Pain or Discomfort at the Injection Site

After PRP injections, some patients may experience mild pain, tenderness, or discomfort at the site of injection. This is a normal response to any injection and usually subsides within a few minutes to hours. During this period over-the-counter painkillers, such as Paracetamol, can help alleviate any discomfort.


Swelling occurs as part of the body’s natural healing response. It is usually mild and temporary, resolving within  48 hours. Applying cold compresses to the area for short periods of time can help reduce swelling. Additionally, following any post-treatment instructions provided by your healthcare professional is also important.


Next we have bruising. This is when small blood vessels near the injection site are disrupted during a procedure. This condition can vary in severity and may appear as discolouration of the skin. It typically resolves on its own over time, similar to how a bruise from a minor injury would heal. Avoiding blood-thinning medications or supplements (such as omega-3) prior to treatment can help reduce the risk of excessive bruising

Redness and Skin Irritation

Another side effect can be temporary redness and skin irritation. This may occur at the injection site following PRP therapy. This is a normal inflammatory response to the treatment. The redness and irritation should subside within a few hours or days. If needed, your healthcare professional may recommend over-the-counter creams or ointments to soothe the area.

Itching or Pruritus

Some individuals may experience mild itching or pruritus at the injection site after PRP therapy. This is typically a temporary side effect and can be managed with over-the-counter topical antihistamines or by following your healthcare professional’s recommendations. It is important to avoid scratching the area to prevent any potential complications.


Moreover, in rare cases, there is a slight risk of infection associated with any injection-based treatment. Choosing a reputable healthcare professional who follows strict sterile techniques and guidelines is important to minimise this risk. If you notice increasing pain, redness, warmth, or discharge at the injection site, it is essential to seek medical attention promptly, as these could be signs of an infection.

Allergic Reaction

Lastly, allergic reactions to PRP therapy. Although extremely rare, this can occur in some patients. However, if you have a known allergy to any component of the PRP preparation, such as the anticoagulant used during the process, it is important to inform your healthcare provider beforehand. They will assess the situation and determine if PRP therapy is appropriate for you or if an alternative treatment option should be considered.

To conclude, the severity and duration of side effects can vary from person to person. Most side effects associated with PRP therapy are mild and temporary, resolving on their own within a short period. It is important to consult with your healthcare professional if you have any concerns or if any side effects persist or worsen. Professionals will be able to provide appropriate guidance and support throughout your treatment journey.

If you would like to learn more about PRP therapy and become a member of the team, click on the button and join us today!

About the Author

Dr. Deepa Panchalingam

Aesthetic Trainer

MBBS BSc (Hons) MSc (Dist) MBCAM

Dr. Deepa utilizes her surgical skills working as an Aesthetic doctor at several successful clinics across London and Berkshire. …


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